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Non-opioid Treatment For Chronic Pain – Groundbreaking Study


A Non-opioid Treatment For Chronic Pain – Cutting Edge Development

Researchers at the Medical College of Wisconsin have discovered a non-opioid treatment for chronic pain that may revolutionize severe pain treatment.  
non-opioid treatment prescription graphic
(c) Public Domain – PHenry
A recent article in the Medical Xpress newsletter covered what may be the new way to treat chronic pain including workers’ compensation injured workers.  

TRPC5 Key To Non-opioid Treatment 

According to the article –  …blocking transient receptor potential canonical 5 (TRPC5) activity reversed touch pain in mouse models of sickle cell disease, migraine, chemotherapy-related pain, and surgical pain. If you wish to find out more, the MCW staff put together a nice video on the research.   The video is a little heavy with medical terms, but the bottom line is a new method of alleviating pain is on the horizon.   While the research is in its infancy, this looks to be a major step in controlling pain.     There are two TRPC5 inhibitors currently in clinical trials for kidney disease and depression.  Pending successful completion of Phase 1 safety tests, these drugs could potentially be fast tracked for use in chronic pain patients. This means that TRPC5 could be a new, non-opioid target for alleviating pain in chronic inflammatory pain conditions that affect so many patients worldwide. Furthermore, our finding that TRPC5 had no effect on non-painful touch means that people can pick up their coffee cup, walk, dress themselves and caress their grandchild without losing tactile perception. Bringing any type of new drug to the market is likely years away unless the drugs are fast-tracked.  The research group is working with mice.  Humans and mice do have very similar pain receptors.  I am sure there are many studies on non-opioid treatment.  This study seems to be the most promising one for having pain relief without the all too familiar complications with opioid use.    


James J Moore - Workers Comp Expert

Raleigh, NC, United States

About The Author...

James founded a Workers’ Compensation consulting firm, J&L Risk Management Consultants, Inc. in 1996. J&L’s mission is to reduce our clients’ Workers Compensation premiums by using time-tested techniques. J&L’s claims, premium, reserve and Experience Mod reviews have saved employers over $9.8 million in earned premiums over the last three years. J&L has saved numerous companies from bankruptcy proceedings as a result of insurance overpayments.

James has over 27 years of experience in insurance claims, audit, and underwriting, specializing in Workers’ Compensation. He has supervised, and managed the administration of Workers’ Compensation claims, and underwriting in over 45 states. His professional experience includes being the Director of Risk Management for the North Carolina School Boards Association. He created a very successful Workers’ Compensation Injury Rehabilitation Unit for school personnel.

James’s educational background, which centered on computer technology, culminated in earning a Masters of Business Administration (MBA); an Associate in Claims designation (AIC); and an Associate in Risk Management designation (ARM). He is a Chartered Financial Consultant (ChFC) and a licensed financial advisor. The NC Department of Insurance has certified him as an insurance instructor. He also possesses a Bachelors’ Degree in Actuarial Science.

LexisNexis has twice recognized his blog as one of the Top 25 Blogs on Workers’ Compensation. J&L has been listed in AM Best’s Preferred Providers Directory for Insurance Experts – Workers Compensation for over eight years. He recently won the prestigious Baucom Shine Lifetime Achievement Award for his volunteer contributions to the area of risk management and safety. James was recently named as an instructor for the prestigious Insurance Academy.

James is on the Board of Directors and Treasurer of the North Carolina Mid-State Safety Council. He has published two manuals on Workers’ Compensation and three different claims processing manuals. He has also written and has been quoted in numerous articles on reducing Workers’ Compensation costs for public and private employers. James publishes a weekly newsletter with 7,000 readers.

He currently possess press credentials and am invited to various national Workers Compensation conferences as a reporter.

James’s articles or interviews on Workers’ Compensation have appeared in the following publications or websites:

  • Risk and Insurance Management Society (RIMS)
  • Entrepreneur Magazine
  • Bloomberg Business News
  • WorkCompCentral.com
  • Claims Magazine
  • Risk & Insurance Magazine
  • Insurance Journal
  • Workers Compensation.com
  • LinkedIn, Twitter, Facebook and other social media sites
  • Various trade publications


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